摘要
目的 :探讨牛磺酸镁配合物保护血管内皮和改善血流变的作用。方法 :冰浴加肾上腺素复制整体血管内皮损伤模型 ,检测血液循环内皮细胞 (CEC)数量和血流变学变化 ,观察牛磺酸镁配合物的作用。结果 :模型大鼠 ,CEC数量明显增加 ;全血比粘度增高 ,血液粘稠度增大 ,红细胞压积增大 ,红细胞变形能力下降 ,聚集能力增高 ;同时 ,血浆内皮素水平增高 ,一氧化氮代谢产物减少 ,一氧化氮合酶活性亦下降。牛磺酸镁配合物能减少模型大鼠的CEC数量 ;降低模型大鼠全血粘度的低切和高切变率 ,减少红细胞压积 ,提高红细胞变形能力 ;血浆内皮素水平下降、一氧化氮代谢产物增多、一氧化氮合酶活性增高。上述作用均呈剂量依赖性。结论 :冰浴加肾上腺素法可作为整体条件下评价血管内皮损伤的模型 。
AIM: To study the protective effects of taurine-magnesium complex (TMC) on endothelium and hemorheology in rats. METHODS: A model of the endothelial damage was made by means of giving rats an injection of adrenaline and making them swim in ice-cold water, then number of circulating endothelial cells (CEC) in whole blood, plasma ET-1 and NO_2^-/NO_3^- content, NOS activity and rheology were determined, respectively. The protective effects of TMC were also observed. RESULTS: An increase in the number of CEC accompanied by abnormal whole blood viscosity, and endothelium-derived ET-1 were observed in model rats. Both the NO_2^-/NO_3^- content and NOS activity were declined significantly in model rats. TMC reduced the number of CEC, resumed NO_2^-/NO_3^- content and NOS activity, and improved the whole blood viscosity in a dose-dependent manner in model rats. CONCLUSION: Ice-cold water bath with adrenaline causes an acute damage of vascular endothelium and abnormal rheology. TMC protects against the injury of vascular endothelium and improves the hemorheology. [
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第11期2101-2104,共4页
Chinese Journal of Pathophysiology
基金
天津市科委"十五"重大攻关项目暨天津市自然科学基金资助项目 (No .0 0 36 0 84 11)
