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肥胖症患者瘦素受体基因外显子4变异特征 被引量：1

Characteristics of exon 4 variation in leptin receptor gene of patients with obesity
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摘要 目的:探讨瘦素受体基因外显子4变异情况及是否与肥胖症相关。方法:选择肥胖症患者犤体质量指数(BMI)≥28kg/m2犦和正常人(18.5≤BMI<23kg/m2)各50例,运用PCR-SSCP方法,检测瘦素受体基因外显子4的变异情况。结果:50例肥胖症患者瘦素受体基因外显子4未发现碱基改变。结论:瘦素受体基因外显子4中519位点变异不是肥胖症的遗传因素。 AIM:To investigate the possible relationship between variant of exon 4 in leptin receptor (LEPR) gene and obesity.METHODS: Genomic DNA was extracted from 50 obese subjects [body mass index (BMI) ≥28 kg/m2] and 50 normal individuals(18.5≤BMI< 23 kg/m2), and the variation of exon 4 was determined by PCR-SSCP method.RESULTS: There was no abnormal change in 50 obese cases during detection.CONCLUSION: Variation of exon 4 in LEPR gene at site 519 is not a genetic factor of obesity.
作者 侯英 丁久立 段滨红 冯琨 王亦薇 李贤厚 朱巍 杨玉芝
机构地区 黑龙江省医院内分泌代谢科
出处 《中国临床康复》 CSCD 2004年第33期7422-7423,共2页 Chinese Journal of Clinical Rehabilitation
基金 黑龙江省自然科学基金资助项目(D00-41)~~
关键词 变异(遗传学) 蛋白质类/遗传学 多态性 限制性片段长度 肥胖症/遗传学 聚合酶链反应 瘦素
分类号 R589.2 [医药卫生—内分泌]
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参考文献11

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同被引文献7

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中国临床康复
2004年 第33期

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