期刊文献+

周期素依赖性激酶5在阿尔茨海默病中的作用

下载PDF
导出
摘要 周期素依赖性激酶5在神经系统发育过程中,可调节轴突生长、神经元分化及迁移。最近研究表明,周期素依赖性激酶5激酶活性失调与阿尔茨海默病的发病有关。本文对周期素依赖性激酶5的生物学特征及其在阿尔茨海默病的作用进行综述。
出处 《国外医学(老年医学分册)》 2004年第6期249-251,共3页 Foreign Medical Sciences(Geriatrics)
  • 相关文献

参考文献1

二级参考文献19

  • 1Nestler EJ, Hyman SE, Malenka RC. Catecholamines. In:Nestler Hyman SE, Malenka RC, editors, Molecular neuropharmacology: a foundation for clinical neuroscience.Beijing: People's Medical Publishing House and McGraw-Hill; 2001. p 182.
  • 2Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3,cdk5 and cdc 2 and the phosphorylation of tau in rat forebrain.FEBS. Lett 2000; 485: 87-93.
  • 3Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser262/356. FEBS Lett 2001;.490: 15-22.
  • 4Greengard P. The neurobiology of slow synaptic transmission. Science 2001; 294: 1024-1030.
  • 5Winder DG, Sweatt JD. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat Rev Neurosci 2001; 2: 461-474.
  • 6Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD. Cocaine and antidepressantsensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 2000; 20:.7571-7578.
  • 7Nishi A, Bibb J, Snyder GL, Higashi H, Naim AC, Greengard P. Amplification of dopaminergic signaling by a positive feedback loop. Proc Natl Acad Sci USA 2000; 97: 12840-12845.
  • 8Liu S J, Wang JZ. Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin. Acta Pharmacol Sin 2002; 22: 183-187.
  • 9Andorfer CA, Davies P. PKA phosphorylations on tau:developmental studies in the mouse. Dev Neurosci 2000; 22:303-304.
  • 10Horsburgh K, Saitoh T. Altered signal transduction in Alzheimer's disease. In: Terry RD, Katzman R, Bick KL,editors. Alzheimer disease. New York: Raven Press Ltd;1994. p 387-404.

共引文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部