受血者受血前HIV、HBV、HCV及梅毒重叠感染的研究

Co-infection of Human Immunodeficiency Virus,Hepatitis C Virus,Hepatitis B Virus and Syphilis in Transfusing Recipients:A Preliminary Research

目的 探讨受血者受血前 HIV、HBV、HCV及梅毒重叠感染。方法 用 EL ISA、双抗体夹心法检测血清HBV标志物、血清抗 - HCV、血清抗 - HIV,用 RPR及 TPPA检测受血者受血前梅毒感染。结果 1980 0例受血者受血前检查中发现血清乙型肝炎 HBs Ag阳性者 2 136例 ( 10 .79% ) ,血清抗 - HCV阳性者 5 76例 ( 2 .91% ) ,血清梅毒 ( RPR法及 TPPA )阳性者 16例 ( 0 .0 8% ) ,血清抗 - HIV阳性者 14例 ( 0 .0 7% ) ,其中 HBV、HCV重叠感染 74例 ( 0 .375 % ) ;14例抗 - HIV阳性病例中 ,HIV重叠感染 HCV4例 ( 2 8.5 % ) ,HIV重叠感染 HBV2例 ( 14 .2 8% ) ,HIV和 HCV、HBV三重感染 2例 ( 14 .2 8% )。结论 在受血者受血前检查中 HIV感染者与 HCV、HBV重叠感染率较高 ,进行全面检查不仅可以避免医疗纠纷的发生 。

OBJECTIVE To investigate the co-infection of HIV, HCV, HBV and syphilis in recipients before transfusion. METHODS Anti-HIV, -HBV, and -HCV were detected by sandwich enzyme-linked immunosorbent assay (ELISA) in the serum from 12 000 cases transfusing recipients, and syphilis was checked by rapid plasma reagin (RPR) and conformed by PCR. RESULTS Among the 19 800 cases transfusing recipients, the positive rates of HBsAg, anti-HCV, syphilis (RPR and PCR) and anti-HIV were 10.79%, 2.91%, 0.08% and 0.07%, respectively; 28.6% HIV infected cases were found anti-HCV positive, and 14.28% HIV infected cases were HBsAg positive, and 2 cases were confirmed co-infected by HIV, HCV and HBV. CONCLUSIONS Co-infection of HCV and HBV is found among HIV infected patients in transfusing recipients, the over-all examination contributes not only to avoi medical dispute, but to improve clinical therapy of patients.