哌拉西林/他唑巴坦治疗34例住院患者下呼吸道感染的临床研究

Piperacillin/tazobactam Treatment of 34 Inpatients with Lower Respiratory Tract Infection

目的 评价哌拉西林 /他唑巴坦对住院患者下呼吸道感染的疗效和安全性。方法 对 34例下呼吸道感染住院患者 ,静脉滴注哌拉西林 /他唑巴坦 ,观察患者临床症状、肺部体征、实验室检查、影像学改变、痰培养结果以及可能出现的皮肤、神经精神系统、心血管、泌尿系统的症状。结果 治疗有效率为 91.2 % ,痊愈率为 6 1.8% ,细菌清除率为 82 .1% ,不良反应发生率为 5 .9% ,无实验室检查异常。结论 哌拉西林 /他唑巴坦治疗住院患者下呼吸道感染疗效显著 ,不良反应轻微。

OBJECTIVE To evaluate the efficacy and safety of piperacillin/tazobactam in the treatment of inpatients with lower respiratory tract infection. METHODS To observe patients′ clinical manifestation, pulmonary signs, laboratory results, chest X ray films, bacterial culture changes and possible adverse reactions of dermis, neuropsychic system, cardiovascular system and urinary system after intravascular administration of piperacillin/tazobactam. RESULTS The effective rate and the cure rate were 91.2% and 61.8%, respectively, the bacterial eradication rate was 82.1%, the rate of adverse reactions was 5.9%, there were no abnormal laboratory finding. CONCLUSIONS Piperacillin/tazobactam had good efficacy and mild adverse reactions in the treatment of inpatients with lower respiratory tract infection.