抗生素相关性腹泻临床研究

Antibiotic-Associated Diarrhea:Clinical Research and Prevention

目的 了解医院感染抗生素相关性腹泻临床特点 ,提出预防控制措施。方法 回顾分析 1996年 1月～2 0 0 2年 12月儿科住院病历 7314份 ,获得医院感染抗生素相关性腹泻 10 2例 ,与医院感染非抗生素相关性腹泻2 6例作对照分析。结果 医院感染抗生素相关性腹泻较非抗生素相关性腹泻发病率高、临床症状重 ;抗生素使用时间≥ 5 d,腹泻感染率明显升高 ,联合使用抗生素种类越多 ,腹泻感染率越高。结论 合理使用抗生素 ,严格控制广谱抗生素的使用 ,是预防控制医院感染抗生素相关性腹泻的关键措施。

OBJECTIVE To investigate the clinical characteristic of antibiotic-associated diarrhea in nosocomial infection and make measures to prevent and control it. METHODS The clinical data of 7 314 hospitalized children from Jan 1996 to Dec 2002 were analyzed. One hundred and two cases of antibiotic-associated diarrhea in nosocomial infection were given and analyzed in comparison with 26 cases of non-antibiotic-associated diarrhea in nosocomial infection. RESULTS There were more incidence and clinical symptoms in antibiotic-associated diarrhea than that in non-antibiotic one in nosocomial infection. Infection rate of diarrhea increased while the antibiotics were used more than five days. The more antibiotics were used, the more infection rate of diarrhea was. CONCLUSIONS Rational use of antibiotic and rigorous control use of antibiotic were the key measures to prevent and control the antibiotic-associated diarrhea in nosocomial infection.