乙氧呋草黄对映体的手性拆分研究

Study on the Chiral Separation of the Enantiomers Ethofumesate

进行了除草剂乙氧呋草黄对映体在自制的纤维素-三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)高效液相色谱手性柱上的拆分研究。使用了两种流动相体系:正己烷-异丙醇;石油醚-异丙醇,并分别考察了流动相中加入的极性改性剂对手性拆分的影响。试验结果显示,乙氧呋草黄在两种流动相体系中都能得到最好的拆分,但正己烷体系优于石油醚体系,流动相中的极性改性剂的含量减少有利于手性拆分。在正己烷流动相条件下考察了柱长、温度对手性拆分的影响。对对映体的拆分机理进行了讨论。

The direct separation of the two enantiomers of ethofumesate on the CDMPC chiral stationary phase of the high-performance liquid chromatograph was studied. Two mobile phases, n-hexane-isopropane and petroleum ether-isopropane, were used, and the effect of isopropane content was investigated. Satisfactory results were obtained in both systems. The influence of column length and temperature were also studied in n-hexane system.