Tanis与2型糖尿病及炎症反应
摘要
Tanis为新发现的由 189个氨基酸残基组成的蛋白质 ,在肝脏、脂肪和骨骼肌等组织均有此基因的表达。Tanis基因表达与循环中的葡萄糖及胰岛素浓度呈负相关 ,与甘油三酯呈正相关 ;Tanis具有拮抗胰岛素的作用 ,抵抗过氧化氢引起的细胞凋亡 ,并可能作为血清淀粉样蛋白A的受体在 2型糖尿病、炎症反应和心血管疾病的发生、发展中起着重要的作用。Tanis的发现将为治疗 2型糖尿病和心血管疾病提供一个新的靶点。
出处
《国外医学（内分泌学分册）》
2004年第6期379-381,共3页
Foreign Medical Sciences(Section of Endocrinology)
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