幽门螺杆菌感染与冠心病的关联研究

Study on the Association of Helicobacter Pylori Infection and Coronary Heart Disease

目的:探讨幽门螺杆菌(helicobaeter pylori,HP)感染与冠心病(coronary heart disease,CHD)发生的关系。方法:用胃镜结合病理学检测了55例CHD患者和60例其他心血管疾病患者的HP感染情况,并进行血清脂质浓度的检测。结果:39例CHD患者HP阳性与对照组26例HP阳性比较差异显著(OR:2.71,X2=5.742,P<0.05),HP阳性病例的血清TG、TC和LDL浓度明显高于HP阴性病例(P<0.05)。结论:HP感染与CHD的发生可能有明显的关联,其机理可能是HP感染可导致血管内皮细胞功能紊乱及脂质代谢异常,诱发利促进CHD的发生。

Objective: To explore the association of helicobacter pylori infection and coronary heart disease. Method: The HP infectious status of 55 CHD and 60 other cardiovascular disease patients were assayed by fabric gastric glass and pathology, and the blood lipids were analyzed. Results: The difference was very obvious between the HP positive and negative ratc of CHD (OR=2. 71, X2 =5. 742,P<0. 05). Tile content of serum TG, TC, LDL of HP positive patients were very higher tile negative (P<0. 05). Conclusion: Our findings revealed a significantly higher association between HP infection and CHD.