慢性活动性胃炎的诊断标准及其与Hp、GH关系

Diagnostic Standard of Chronic Active Gastritis and Its Relations with Hp、GH

目的 :探讨慢性活动性胃炎诊断标准及其与 Hp、GH关系。方法 :从 72 0例胃镜活检标本中 ,选取慢性活动性胃炎 5 6 1例 ,尸检儿童正常胃体、胃窦标本 4 0例 ,采用 HE、慢性胃炎三重染色法和免疫组化 L CA染色 ,光镜下观察。结果 :Hp感染程度与慢性活动性胃炎活动度关系密切 ,且随着 Hp感染程度增加 ,炎症的活动性增强。 Hp检出率98.2 2 % ,Hp螺旋体长平均 2～ 3.5μm,横切面直径 0 .3～ 0 .6μm,Hp球形体直径 0 .7～ 1.2μm,同一张切片中 Hp螺旋体横切面直径与球形体直径之比约为 1∶ 2 ,且 Hp螺旋形和球形体往往同时存在。 GH长 4～ 6μm,横径 0 .5～ 1μm,检出率为 1.78% ,结论 :Hp和 GH为慢性活动性胃炎的病因 ,Hp常见 ,GH少见得多。 Hp和 GH均能吸引中性白细胞游出 ,形成慢性活动性胃炎的启动机制。中性白细胞渗出浸润应为确定慢性活动性胃炎活动性病变的唯一标准。

Objective:To study the diagnostic standard of chronic active gastritis and its relations with Hp、GH of chronic active gastritis.Method:561 specimens of endoscopic gastric biopsy selected from 720 patients and 40 normal gastric specimens of children in autopsy were stained by HE and triple stain method of chronic gastritis and LCA immunohistochemical stain and observated under microscope.Result:The infected grades of Hp and the active degrees of chronic active gastritis were closely related. With the increase of the infected grade of Hp ,the active degrees of chronic active gastritis increased correspondingly. The rate of detection in Hp was 98.22%.The length of spiral form Hp was 2.5 to 3 μm,wide 0.3 to 0.6 μm.The diameter of coccoid form of Hp was 0.7～1.2 μm.The rate between the diameter of spiral and coccoid form in the same slide was 1∶2.Hp spiral and coccoid form often existed simultaneously.GH was 4～6 μm long and 0.5～1.0 μm wide and the rate of detection was 1.78%.Conclusion:Hp and GH are the etiology of chronic active gastritis and can attract the emigration of leucocytes,wich is starting mechanism.Therefor the infiltration of neutrophils is only the diagnostic standard of chronic active gastritis.