哮喘患者血浆内源性一氧化碳的水平及意义

Level and Significance of Endogeous Carbon Monoxide of Patients with Asthma

目的 :探讨一氧化碳 (carbon monoxide,CO)在哮喘发病中的作用和意义。方法 :应用 Chalmers血红蛋白结合及联二亚硫酸盐还原法测定支气管哮喘急性发作期、缓解期 2 6例及正常对照组 2 8例的血浆一氧化碳水平 ,同时测定了一氧化氮 (NO2 :/ NO3:)的水平及 Pa O2 、FEV1 .0 %。结果 :支气管哮喘患者急性发作期血浆 CO水平及 NO2 :/ NO3:水平均高于缓解期及正常对照组 ,且与 Pa O2 、FEV1 .0 %呈负相关 ,与 NO2 :/ NO3:水平呈正相关 (P<0 .0 1)。结论 :内源性 CO参与了哮喘的病理生理过程。

Objective:To investivate the role and significance of carbon monoxide(CO) in the pathogenesis of asthma.Methods:We measured the levels of CO and nitric oxide (NO 2:/NO 3:) 、PaO 2 、FEV1.0% in 26 asthmatic cases and 28 cases of normal subjects.Results:Asthmatic subjects In acute attack stage had increased levels of CO than normal control subjects and stable stage (P<0.01).And the elevation of plasma CO correlated natively with PaO 2 and FEV1.0%,positively with NO 2:/NO 3:.Conclusions:The endogenous CO is involved in the pathophysiology in asthma.