肾血管平滑肌脂肪瘤的临床病理及免疫组化分析

Clinicopathological Features and Immunohis-Tochemical Analysis of Renal Angiomyolipoma

目的 :探讨肾血管平滑肌脂肪瘤 (AML )的临床病理特征及免疫表型。方法 :应用免疫组织化学方法检测单克隆抗体 HMB4 5、SMA、Actin、S- 10 0蛋白、CD34、F RAg及 CK在 2 0例肾 AML中的表达情况 ,并观察其临床病理特点。结果 :肾 AML由畸形血管、平滑肌细胞及脂肪混合构成。免疫表型 :肿瘤细胞特征性表达 HMB4 5、SMA、Actin。结论 :肾 AML的病理形态变化多样 ,3种主要成分的比例和分布各异 ,特征性免疫组化标记可为诊断提供依据。

Objective:To study the clinicopathological features and immunophenotypes of renal angiomyolipoma (AML).Methods:In order to observe the clinicopathological features and immunophenotypes,20 Cases of renal angiomyolipoma were studied by immunohistochemical staining for monoclonal antibodies including HMB45,SMA,Actin,S-100 protein,CD34,FⅧRAg and CK.Results:Renal angiomyolipoma mainly consists of abnormal Vascular,smooth muscle cells and mature fat cells.Immunohistochemically,the tumor cells were positive for HMB45,SMA and Actin.Conclusions:The pathological features of the renal angiomyolipoma are variant.The proportion and distribution of the three main component part in renal angiomyolipoma are varied from each other. Its immunophenotype is helpful in diagnosis.