超短效β受体阻滞剂对气管插管应激反应的预防

Effects of Ultra-Short-Acting β-Blocker on Stress Response to Tracheal Intubation

目的:为预防气管插管应激反应,采用插管前静脉注射盐酸艾司洛尔,观察疗效和安全性。方法:选择60例择期手术患者随机分为 3组(A、B、C)分别于麻醉诱导前静脉注射艾司洛尔 1mg/kg(A:n=20),2 mg/kg(B:n=20)和生理盐水 10 ml(C:n=20)。结果:A、B两组用药后心率减慢(P<0.05),气管插管后心率和血压增加不明显,C组插管后心率和血压均超过对照水平(P<0.01)。结论:艾司洛尔能有效抑制气管插管引起的心血管反应,且无明显血液动力学影响。

Objective:To investigate the clinical effect and security of preventing stress response to tracheal intu- bations with Esmolol. Methods: 60 cases of ASA Ⅰ～Ⅱ were randomly divided into three groups, in which different dose of esmolol were given before induced anesthesia: Group A (n=20): 1mg/kg Esmolol, Group B (n=20): 2 mg/kg Esmolol and Group C (n= 20): 10 ml Natrium chloride. Results:HR decreased after the uses of Esmolol in Group A and B (n<0.05). HR and Bp increased insignificantly in Group A and B, but significantly in Group C (n<0.01). Conclu- sion: Esmolol could effectively inhibit the stress response caused by intubations without significant hemodynamic changes.