老年呼吸系统感染患者外周血T淋巴细胞rDNA转录活性检测及其临床意义

Determination of rDNA Transcriptional Activity of Venous T Lymphocyte in Aged Patients with Respiratory System Infection

目的 了解老年呼吸系统感染时 T淋巴细胞 r DNA的转录活性 ,并探讨其临床意义。方法 测定了 2 5例老年呼吸系统感染患者及感染治愈后外周静脉血 T淋巴细胞核仁区相关的嗜银蛋白 (Ag- NORs)含量 ,并以 15例正常老年人作为对照。结果 老年呼吸系统感染组外周静脉血 T淋巴细胞 Ag- NORs明显减低于正常对照组 ,统计学处理差异有显著性 (P<0 .0 1)。结论 老年呼吸系统感染患者外周静脉血 T淋巴细胞 r DNA转录活性减低 ,它可能参与了老年呼吸系统感染的病理生理变化。

OBJECTIVETo understand the rDNA transcriptional activity of T lymphocyte and approach to it′s clinical significance in aged patients with respiratory system infection. METHODSThe content of Ag-NORs in peripheral T lymphocyte was determined in the 25 aged patients with respiratory system infection and 15 aged healthy persons as control. RESULTSThe content of Ag-NORs in patients with respiratory system infection was significantly lower than that in the control one. CONCLUSIONS The transcription activity of T lymphocyte was lower in aged patients with respiratory system infection. It may contribute to the pathophysiological changes in aged patients with respiratory system infection.