重庆地区铜绿假单胞菌医院感染及耐药性分析

Hospital Infection and Resistance of Pseudomonas aeruginosa: An Analysis

目的 了解铜绿假单胞菌 (PA)引起医院感染的特点以及对抗生素的耐药性的变化趋势。方法 对 2 0 0 0～ 2 0 0 2年分离出的 32 5株铜绿假单胞菌选用 12种抗生素进行药敏实验 ,按 NCCL S标准判断。结果 该菌对氨基糖苷类、环丙沙星、哌拉西林等耐药率呈明显上升趋势 ;对碳青酶烯类药物亚胺培南耐药率达 15 .7% ,对第三代头孢菌素的敏感率最低。结论 了解铜绿假单胞菌的耐药现状 ,有利于为临床合理用药提供依据。

OBJECTIVETo explore the trend on hospital infection leaded by Pseudomonas aeruginosa (PA) and the resistance to antibiotics of PA. METHODSDrug-resistance test was performed on 325 strains of PA by using 12 kinds of ordinary antibiotics with drug sensitive experiment based on the standard of the NCCLS from 2000 to 2002. RESULTSThe drug-resistance rate of aminoglycosides, ciprofloxacin and piperacillin appeared increasing trend, the drug-resistance of imipenem was 15.7%, the sensitivity rate of the third generation cephalosporins was the lowest. CONCLUSIONS The status of resistance of PA must be investigated, in order to provide evidence for clinical rational drug utilization.