奥硝唑治疗口腔厌氧菌感染的临床与实验研究

Efficacy of Ornidazole and Tinidazole Against Periodontitis and Pericoronitis: A Clinical and Experimental Study

目的 了解口腔厌氧菌感染的菌群分布及奥硝唑治疗口腔厌氧菌感染的疗效。方法 采用双盲随机方法选择 6 0例口腔厌氧菌感染患者 ,其中受试组 (奥硝唑 ) 30例和对照组 (替硝唑 ) 30例进行治疗 ,在治疗前后作厌氧菌培养 ,观察临床疗效和厌氧菌清除率 ,并进行比较。结果 口腔感染厌氧菌与口腔正常厌氧菌种群一致 ,奥硝唑总有效率 83.3% ,细菌清除率 91.7% ;替硝唑总有效率 73.3% ,细菌清除率 88.4 % ,二者间差异无显著性(P>0 .0 5 )。结论 奥硝唑用以治疗口腔厌氧菌感染疗效显著 ,口腔厌氧菌培养应注意标本采样技术规范化。

OBJECTIVE To find out the bacteria distributing in periodontitis and pericoronitis and the efficacy of ornidazole against them. METHODS In this random double-blind trial, 30 periodontitis and pericoronitis patients were treated by ornidazole, and 30 patients treated by tinidazole served as a control group. The clinical efficacy and the rate of killing anaerobic bacteria were observed. RESULTS The effective rate was 83.3% in test group and 73.3% in control group respectively and the rate of killing anaerobic bacteria was 91.7% and 88.4%, respectively. There were no significant differences between two groups (P>0.05). CONCLUSIONS Ornidazole shows obvious therapeutic effects on infection with anaerobic bacteria and the sample collecting should be normative in culturing anaerobic bacteria.