慢性移植肾肾病的治疗方法探讨

The study in the treatment of chronic allograft nephrophathy

目的 :探讨治疗慢性移植肾肾病 (CAN)的有效途径。方法 :按照不同治疗方案将CAN2 34例患者分为 4组 ,比较各组的治疗效果。结果 :2 34例的总有效率为 34.2 % ,4组的有效率分别为 19.3%、32 .6 %、4 6 .9%、4 2 .9%结论 :随着免疫抑制方案的不同 ,临床上所见慢性排斥发生机制也有差别 ,治疗上宜根据患者具体情况 ,采取相应的综合措施 ,抗病毒、降血脂、降血压、治疗糖尿病等 ,可取得一定效果 ;结合传统中药治疗 ,可明显提高有效率。

Objective:To investigate effective therapeutic measure for chronic allograft nephrophathy(CAN).Methods:Patients suffered from CAN were divided into four groups according to their different therapies. 57 cases whose immunosuppressants were added up or changed belonged to the first group; the second group included 92 cases who adopted the comprehensive measures; there were 64 cases in the third group,their MMF was added up to 1.5 ～ 2.0g/d and injected Chinese medicines, Astragalus Root(Huangqi) and Red Sage Root(Danshen), at the same time; the fourth group consisted of 21 cases, the medication of prostatin was used on the basis of the therapy in the third group. The therapeutic effect of different groups were comparative studied and analysed.Results:The mean rate of efficiency in 234 cases was 34.2%, The effective power of four groups were 19.3%, 32.6%, 46.9% and 42.9%, respectively. There was a significant difference between the first group and the third group.Conclusions:The mechanism of CAN were different from the different immunosuppressive therapies; the treatment should be comprehensive based on the patients' conditions. Traditional Chinese medicines in combination with immunosuppressive drugs can improve the therapeutic effect.