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细胞间隙连接通讯与肿瘤 被引量：14

Gap junctional intercellular communication and cancer
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摘要 细胞间隙连接通讯 (GJIC)在多细胞动物细胞的生长、分化和凋亡等生理过程中发挥着重要调节作用。研究表明大多数转化细胞和肿瘤细胞GJIC功能减弱或消失。阻止肿瘤促进剂对细胞GJIC功能的抑制或恢复癌细胞GJIC功能将对肿瘤的预防和治疗具有重要意义。 Gap junctional intercellular communication (GJIC) has been specu la ted to be a necessary biological function of metazoan cells for the regulation o f growth control, differentiation and apoptosis of normal progenitor cells. Rese arches show that most transformed cells and tumor cells have reduced or abolished GJIC. The prevention of the down regulation of GJIC by the tumor promoters or the restoration of GJIC in neoplastic cells may have potential in prevention and therapy of cancer.
作者 孙华 刘耕陶
机构地区 中国医学科学院.中国协和医科大学药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2004年第11期1205-1208,共4页 Chinese Pharmacological Bulletin
关键词 间隙连接通讯 肿瘤 双环醇 gap junctional cancer bicyclol
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献16

  • 1Jeong SH, Cho MH, Cho JH. Effects of cadmium on gap junctional intercellular communication in WB-F344 rat liver epithelial cells[J]. Human & Experimental Toxicology, 2001,20(11):577-83.
  • 2Leithe E, Cruciani V, Sanner T et al. Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C[J]. Carcinogenesis, 2003,24(7):1239-45.
  • 3Lars-Oliver K, Pauline P, Niloofar AA et al. 2-Methyl-1, 4-naphthoquinone,vitamin K3,decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade[J]. Cancer Res, 2002,62(17):4922-8.
  • 4Edger R,Hanne O. Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells[J]. Carcinogenesis, 2001,22(9):1543-50.
  • 5Nagy JI, Li WE. A brain slice model for in vitro analyses of astrocytic gap junction and connexin43 regulation: actions of ischemia, glutamate and elevated potassium[J]. Eur J Neurosci, 2000,12(12):4567-72.
  • 6Niloofar AA, Wilhelm S, Helmut S. (-)-Epicatechin effects in rat liver epithelial cells: Stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylthorbol-13-acetate[J]. Biochem Pharm, 2002,63(12): 2145-9.
  • 7Trosko JE, Chang CC. Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer[J]. Mutat Res, 2001,480(1):219-29.
  • 8Kang KS, Yun JW, Yoon B et al. Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA[J]. Cancer Lett, 2001,166(2):147-53.
  • 9Edgar R, Hanne O. Role of PKC and MAPK kinase in EGF-and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells[J]. Carcinogenesis, 2001,22(9):1543-50.
  • 10Kyung SK, Byeong CK, Beom JL et al. Preventive effect of epicatechin and ginsenoside Rb2 on the inhibition of gap junctional intercellular communication by TPA and H2O2[J]. Cancer Lett, 2000,152(1):97-106.

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中国药理学通报
2004年 第11期

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