摘要
脑内微透析取样技术是一种连续灌注并采集活体动物特定脑区内灌流液的新方法。脑缺血及再灌期间脑细胞外液中兴奋性氨基酸、单胺类递质和乙酰胆碱等神经递质紊乱而致脑损伤。用微透析取样技术研究动物急性脑缺血及再灌后神经递质的动态变化 ,可真实地反映活体动物神经递质的变化情况。
Cerebral microdialysis is a new sampling method that collects the perfusates from the specific brain region continuously. Disorders of extracellular excitatorary amino acids, monoamines and acetylcholine transmitters release cause brain injury during the cerebral ischemia and reperfusion. Microdialysis has been used to study the dynamic change of neurotransmitters during the acute cerebral ischemia and reperfusion lately, and the real change of neurotransmitters has been monitored in animals brain. The present paper reviews the progress on the microdialysis and its application in the study of neurotransmitters in cerebral ischemia animals in the world.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2004年第11期1209-1211,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目
No 3 0 171185
北京自然科学基金资助项目
No 70 12 0 3 3
关键词
微透析
脑缺血
神经递质
microdialysis
cerebral ischemia
neurotransmitters
