摘要
醋酸诺美孕酮 (nomegestrolacetate )为 19 去甲 孕酮衍生物。近年研究发现 ,诺美孕酮不仅可用于口服避孕或与雌二醇联合应用于激素替代疗法 ,而且还是一种选择性雌激素酶调节剂 ,可抑制硫脂酶、17β 羟基甾醇水解酶 ,增强磺基转移酶活性 ,减少雌二醇的生成 ;有效逆转乳腺癌细胞多药耐药性 ,为乳腺癌的治疗提供了一个新途径。体外实验显示 ,诺美孕酮可有效抑制子宫内膜增生。本文就诺美孕酮的药理作用及近年来在抗乳腺癌及抗子宫内膜增生方面的研究进展加以综述。
Nomegestrol acetate, 19-norprogesterone de ri vatives, has been used for oral contraception. Recently, studies showed that nom egestrol was a selective estrogen enzyme modulator (SEEM). Nomegestrol is capabl e of inhibiting estrone sulfatase and 17-beta-hydroxysteroid dehydrogenase (17 beta-HSD) and increasing the activity of sulfotransferase,which will provide a new option in the treatment of breast cancer. In addition, nomegestrol has stro ng reversal effects on multidrug resistance in breast cancer cells. In vitro, nomegestrol also exhibits as an inhibitor on endometrial proliferation in uter us. These advances will be introduced in the present review.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2004年第11期1215-1217,共3页
Chinese Pharmacological Bulletin
关键词
诺美孕酮
乳腺癌
选择性雌激素酶调节剂
多药耐药性
子宫内膜增生
nomegestrol acetate
breast cancer
elective estrogen enzyme modulators
multidrug resistance
endometrial proliferation
