普罗布考对高密度脂蛋白胆固醇代谢的影响及其作用机制

Effects of probucol on the metabolism of high density lipoprotein cholesterol and their mechanism

普罗布考是一种调脂药 ,其在降脂同时显著降低了血浆HDL C含量却能抗动脉粥样硬化。高密度脂蛋白 胆固醇 (HDL C)在体内的代谢过程目前尚未清楚 ,有研究表明普罗布考通过促进胆固醇逆向转运途径而抗动脉粥样硬化。文章综述普罗布考对体内HDL C代谢的影响及其作用机制。

Probucol is a hypolipidemic agent with a unique pharm ac odynamic and clinical profile. It has a significant antiatherosclerogenic role a lthough it causes a marked decrease in serum high-density lipoprotein (HDL)-ch olesterol levels. The metabolism of HDL in vivois unclear. Some preliminary investigations suggest a beneficial effect in enhancing reverse cholesterol tra nsport which contributes to antiatherosclerosis of probucol. This paper reviews the mechanism of HDL-lowering effects of probucol.