Ar^+激光辐照下离体猪鼻咽组织的热响应特性

Thermal Response of Porcine Nasopharynx Tissue in Vitro under Irradiation of Argon Ion Laser

为了获得用于鼻咽癌(NPC)光活检的Ar+激光对鼻咽组织的安全光剂量阈值,实验测定了离体猪鼻咽组织在Ar+激光辐照下不同位置的温度分布,重点研究了辐照功率密度和波长对组织中温度分布的影响。实验结果表明,组织中的温度分布与探测位置、激光波长以及激光辐照功率密度有关。在同一波长激光辐射下,组织中的温度随着辐照激光功率密度的增大而增大,当辐照功率密度达到185W/cm2时,鼻咽组织黏膜下层的温度可超过415℃;在相同功率密度激光的辐照下,波长为5145nm的激光照射鼻咽组织时的光热效应较488nm波长明显。

In order to get photodisruption threshold of porcine nasopharynx tissue in nasopharynged carcinoma optical biopsy, temperature distributions in the porcine nasopharynx tissue were measured under irradiation of argon ion laser at the wavelength of 488 nm and 514.5 nm, respectively. The dependence of the temperature distribution on the measuring position and irradiation power density, as well as wavelength was studied in detail. Experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly affected by measuring position and the power density, as well as wavelength of irradiation laser. The temperature in the porcine nasopharynx tissue is increased with the increasing of the power density of irradiation laser, and the maximal temperature can be higher than 41 5℃ when the power density reaches 1 85 W/cm 2. The optical thermal effect at the wavelength of 514 5 nm is more remarkable than that of 488 nm under the irradiation of same power density.