原发性肝癌行同种异体原位肝移植治疗的疗效评价

Effective evaluation of liver transplantation for hepatocellular carcinoma

目的 总结肝癌患者肝移植术后的疗效 ,探讨肝癌患者肝移植的适应证。方法 收集我院 2 0 0 0年 8月至 2 0 0 3年 12月进行的 4 3例肝癌肝移植患者的资料 ,对手术后的生存期进行分析 ,并进行随访。结果 最长随访时间 3年零 9个月 ,全组死亡 18例 ,仍存活 2 5例 ,其中 7例带瘤生存。死亡的病例中 ,死于肿瘤复发 12例 ,围手术期死亡 3例 ,分别死于腹腔感染 ( 1例 )、出血 ( 1例 )及急性肾功能衰竭 ( 1例 ) ,其他原因死亡 ( 3例 )。以寿命表法计算 ,1年生存率为 85 5 % ,2年生存率为6 5 5 % ,3年生存率为 4 3 0 %。结论 肝移植为晚期肝癌的治疗提供了一种新的手段 ,部分患者可获得较长期的无瘤生存。

Objective To evaluate the effect of liver transplantation for hepatocellular carcinoma and to explore the suitable indication for liver transplantation for advanced primary hepatocellular carcinoma. Method Clinical data were collected and studied with 43 patients with cirrhosis who had unresectable hepatocellular carcinoma and who underwent liver transplantation from August,2000 to December, 2003 All the survived patients were followed up Results The longest following period was 45 months 18 patients died by the end of the April, 2004 The 1 year survival rate was 85 5%, the 2 year survival rate 65 5%, the 3 year survival rate was 43 0% Conclusion In our country, some advanced primary hepatocellular carcinoma without extrahepatic metastasis is still indicated for liver transplantation Some patients could have the opportunity to survive relatively long time