妊娠期糖尿病患者妊娠晚期血脂水平变化与新生儿出生体重的关系

Maternal serum lipid at 36-42 weeks′ gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus and type 1 and type 2 diabetes mellitus

目的探讨妊娠期糖尿病患者妊娠晚期血脂水平变化与新生儿出生体重的关系。方法采用酶法测定40例妊娠期糖尿病孕妇(妊娠期糖尿病组)、30例1型糖尿病孕妇(1型糖尿病组)、30例2型糖尿病孕妇(2型糖尿病组)及30例正常孕妇(正常妊娠组)妊娠晚期血脂水平。同时测定4组孕妇所分娩的新生儿出生体重。结果(1)妊娠期糖尿病组、1型糖尿病组、2型糖尿病组及正常妊娠组血清甘油三酯水平分别为(40±14)mmol/L、(29±08)mmol/L、(41±25)mmol/L及(27±09)mmol/L;总胆固醇水平分别为(65±30)mmol/L、(62±28)mmol/L、(64±32)mmol/L及(60±31)mmol/L;低密度脂蛋白胆固醇水平分别为(33±13)mmol/L、(32±13)mmol/L、(33±11)mmol/L及(32±10)mmol/L;高密度脂蛋白胆固醇水平分别为(16±05)mmol/L、(14±05)mmol/L、(15±04)mmol/L及(16±04)mmol/L。妊娠期糖尿病组及2型糖尿病组甘油三酯水平明显高于正常妊娠组及1型糖尿病组(P<001)。(2)妊娠期糖尿病组、1型糖尿病组、2型糖尿病组及正常妊娠组的新生儿出生体重分别为(4108±544)g、(3323±457)g、(4111±263)g及(3463±516)g。(3)妊娠期糖尿病组、1型糖尿病组、2型糖尿病组新生儿出生体重,与血清甘油三酯水平呈明显的正相关(r=039,P<001)。

Objective To investigate the levels of serum lipid at 36 42 weeks' gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus (GDM) and type 1 and type 2 diabetes mellitus (DM) Methods This study included 30 normal pregnant women, 40 patients with GDM, 30 patients with type 1 DM and 30 with type 2 DM Subjects with complications including hypertension or thyreogenic diseases were excluded Fasting serum triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured by enzymatic method Results (1) Serum triglyceride levels in pregnant women with GDM, type 1 DM, type 2 DM and normal controls were (4 0±1 4) mmol/L ,(2 9±0 8)mmol/L, (4 1±2 5)mmol/L and(2 7±0 9)mmol/L respectively; the total cholesterol levels were(6 5±3 0)mmol/L,(6 2±2 8) mmol/L,(6 4±3 2)mmol/L and(6 0±3 0)mmol/L respectively; low density lipoprotein cholesterol levels were(3 2±1 3)mmol/L, (3 2±1 3)mmol/L,(3 3±1 1) mmol/L and(3 2±1 0)mmol/L respectively; high density lipoprotein cholesterol levels were(1 6±0 5)mmol/L, (1 4±0 5)mmol/L, (1 5±0 4)mmol/L and(1 6±0 4)mmol/L respectively; the newborn weights were(4108±544)g,(3323±457)g,(4111±263)g, and(3463±516)g respectively Triglyceride levels in pregnant women with GDM and type 2 DM were significantly higher than in normal controls and type 1 DM patients ( P <0 01) (2) Triglyceride levels correlated with birth weights independently ( r =0 39, P <0 01) Conclusions Triglyceride levels at 36 42 weeks′ gestation were elevated in pregnant women with GDM and type 2 DM, suggesting that they might have more obvious insulin resistance In pregnant women with DM, a positive and significant correlation was found between triglyceride levels and newborn weights