雷贝拉唑与冸妥拉唑治疗反流性食道炎的疗效比较

COMPARISON OF THE EFFICACY OF RABEPRAZOLE AND PANTORAZOLE IN THE TREATMENT OF REFLUX ESOPHAGITIS.

目的 :比较雷贝拉唑与冫半妥拉唑治疗反流性食道炎的疗效。方法 :采用随机、开放、阳性对照临床研究设计 ,将 87例内镜证实的反流性食道炎患者 (洛杉矶分级为 A、 B级 )随机分为 2组 ,A组 4 4例予以雷贝拉唑 2 0 mg qd,B组 4 3例予以冫半妥拉唑 4 0 mg qd治疗 ,分别于 d1、第 1周、第 4周、第 8周 ,观察临床症状如烧心、反酸、胸痛缓解情况 ,并于第 8周复查胃镜了解愈合情况。结果 :治疗后两组症状均明显缓解。雷贝拉唑组 d1、第 1周、第 4周、第 8周临床症状缓解率分别为 6 3%、 88%、 94 %、 96 %,愈合率为 95 .5 %。冫半妥拉唑组 d1、第 1周、第 4周、第 8周临床症状缓解率分别为 38%、6 5 %、 78%、 90 %,愈合率为 90 .6 %。结果 :d1、第 1周、第 4周试验 A、 B组缓解率差异有显著性 (P<0 .0 5 ) ;治疗第 8周虽然 A组缓解率比 B组高 ,但差异无显著性 (P>0 .0 5 )。试验 A B组愈合率差异无显著性 (P>0 .0 5 )。结论 :雷贝拉唑可很快缓解反流性食道炎症状 ,愈合率高 。

Objective:To compare the efficacy of Rabeprazole and Pantorazole in the treatment of reflux esophagitis.Methods:Eighty-seven patients with endoscopically proven reflux esophagitis (Los Angles classification A or B grade) were randomly divided into two groups,44 patients in group A received Rabeprazole 20mg daily,while 43 patients in group B received Pantorazole 40mg daily.Reflux symptoms including heartburn, regurgitation and non-cardiac chest pain were evaluated at clinic visits after 1day,1 week,4 weeks and 8 weeks,respectively.At the 8th week,endoscopy was performed to evaluate the healing rate.Results:After treatment,all the symptoms of patients in two groups had improved.Symptom relief was achieved 63%,88%,94%,96% of patients in group A and 38%,65%,78%,90% of patients in group B in the 1st day,1st week,4th week and 8th week,respectively. Healing rate was 95.5% in group A and 90.6% in group B.The symptom improvement rates in the 1st day,1st week and 4th week were significantly different between two groups.And there were no significant difference of symptom improvement rate at the 8th week and esophagitis healing rate has no significant difference between two groups too.Conclusion:Rabeprazole can improve the symptom of reflux esophagitis rapidly,and has high healing rate. Rabeprazole is effective in the treatment of reflux esophagitis.