摘要
[目的]探讨胃脘痛胃黏膜异型增生患者中医微观辨证分型与CdX2基因蛋白表达的意义及与临床随访结果的关系。[方法]应用中医脏腑辨证理论与ABC免疫组化方法对120例胃脘痛胃黏膜异型增生患者进行胃镜下微观辨证分型与CdX2基因蛋白表达的免疫组化分析,同时进行临床随访研究。[结果]胃络瘀滞型与胃络灼伤型患者胃黏膜CdX2基因蛋白表达阳性率(37.5%、66.7%)较胃寒型与胃热型(6.7%、12.5%)明显增高(P<0.01),其中具有完整随访结果者63例,随访时间6-72个月(平均24个月),其癌变者中胃络瘀滞型(76.7%)明显高于未癌变者(27.3%)(P<0.01)。[结论]中医微观辨证分型与CdX2基因蛋白表达有关,对辨别胃黏膜异型增生的癌变性质具有重要意义,胃络瘀滞型胃黏膜异型增生与癌变关系密切,在辨证施治中应给予重视。
<abstract>bjective] To study the relationship between microcosmic distinguish type of gastric precancerous lesions and the expression of CdX2 and its significance in follow - up study. [Methods] One hundred and twenty cases of gastric precancerous lesions (dysplasia and metaplasia) were microcosmic divided distinguishally into four types by endoscopies according to Zang - fu distinguish theory of traditional Chinese medicine. The expression of CdX2 was studied by ABC immunohistochemical method. [Results] The expression of CdX2 in the Type Gastric Net Resort (TGNR) and Gastric Net Burn (TGNB)(37.5 % ,66.7 % ) were higher than that of the groups of Type Gastric Cold (TGC) and Type Gastric Hot ( TGH ) (6. 7 % , 12. 5 % ) ( P < 0. 01). Sixty-three cases were followed up for 6 to 72 months. There were 23 cases of TGNR in the 30 cases of cancer formation group, but 9 in 33 cases of no cancer formation group ( P < 0. 01). [Conclusion] The gastric precancerous lesions (dysplasia and metaplasia ) with TGNR have a close relationship to cancer formation, and need to pay more attention in the distinguish treatment.
出处
《中国中西医结合消化杂志》
CAS
2004年第5期257-259,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金资助项目(No.89170024)
关键词
胃脘痛
异型增生
辨证分型
CDX2基因
<keyword>omachache
precancerous lesion
microcosmic distinguish
CdX2 gene