尿甘氨酰脯氨酸二肽氨基肽酶测定对系统性红斑狼疮患者早期肾损害的诊断价值

Diagnostic value of urine glycyl-proline dipeptidyl aminopepti dase on early renal injury in patients with systemic lupus erythematosus

目的 探讨尿甘氨酰脯氨酸二肽氨基肽酶 (GPDA)对系统性红斑狼疮 (SLE)患者早期肾损害的诊断价值。方法 采用连续检测法测定 4 2例SLE患者和 30例正常人尿GPDA活性 ,并与尿微量白蛋白 (mAlb)相比较。结果 SLE患者尿GPDA及mAlb测定结果均明显高于对照组 (P均 <0 .0 0 1) ,2组指标有显著性差异。结论 尿GPDA能敏感反映SLE患者早期肾损害 。

Objective It is to discuss the diagnostic value of u rine glycyl-prolin e dipeptidyl aminopeptidase (GPDA) on early renal injury in patients with system ic lupus erythematosus (SLE).Methods The urine GPDA activity of 42 patients with SLE and 30 nor mal persons we re measured with continuous monitoring method and compared with urine microalbum in (mAlb).Results The levels of urine GPDA and mAlb of patients with SLE wer e obviously hi gher than those in control group (P<0.001). There was significantly differen t between the two groups.Conclusion Urine GPDA can sensitively reflect early renal injury i n patients with SLE, and it has important clinical diagnostic value.