中国内地人群类风湿关节炎与HLA-DRB1共同表位基因关联性的Meta分析

Meta-analysis of the association between rheumatoid arthritis with HLA-DRB1 in China

目的探讨中国内地人群类风湿关节炎(RA)与人类白细胞抗原(HLA)-DRB1共同表位(SE)基因的关联情况。方法检索已发表的有关中国内地人群RA和HLA-DRB1的文献,进行汇总分析分析。结果14项研究共纳入1118例RA患者和1301名正常对照,中国内地人群RA的关联基因有HLA-DR4[比值比(OR)=4.05,P<0.0001)]、DRB1*0401(OR=2.66,P=0.004)、DRB1*0404(OR=2.10,P=0.02)、DRB1*0405(OR=3.98,P<0.0001)、DRB1*0410(OR=3.36,P=0.008)、SE(OR=2.75,P<0.00001)。其中DRB1*0405是主要基因亚型。结论汇总分析分析不仅证实了DRB1*0405与中国内地人群RA的关联,而且发现了相对少见基因亚型DRB1*0401、DRB1*0404、DRB1*0410与RA的关联,样本大小对基因关联分析的结论有重要影响。

Objective To explore the association between rheumatoid arthritis (RA) with HLA-DRB1 in China. Method The reported articles about HLA-DRB1 RA in China were searched and Meta-analysis was performed. Result Fourteen studies enroll 1118 RA patients and 1301 controls, the associated gene was HLA-DR4 (OR=4.05, P<0.0001), DRB1*0401 (OR=2.66, P=0.004), DRB1*0404(OR=2.10, P=0.02), DRB1*0405(OR=3.98, P<0.0001), DRB1*0410 (OR=3.36,P=0.008), SE(OR=2.75, P<0.000 01). DRB1*0405 was the major genetype. Conclusion The Meta-analysis shows that not only DRB1*0405, but also the rare genetypes are associated with RA in China. Sample size is important in the research of gene association.