婴幼儿血管瘤患者尿液中bFGF的检测及意义

Determination and Significance of bFGF in the Urine of Infantile Hemangioma

目的探讨尿液中碱性成纤维细胞生长因子(bFGF)浓度,以鉴别婴幼儿血管瘤和血管畸形并对血管瘤进行分期。方法采用ELISA法检测29例增生期血管瘤、24例消退期血管瘤、12例血管畸形患儿和10例对照婴幼儿尿液中bFGF浓度。结果增生期血管瘤患儿尿液中bFGF浓度高于消退期血管瘤、血管畸形和对照组,差别有显著性意义(P<0.05),消退期血管瘤、血管畸形与对照组之间尿液中bFGF浓度的差别亦有显著性意义(P<0.05)。结论用ELISA法测定尿液中bFGF简便、易行、可靠,可为临床鉴别血管瘤和血管畸形,并为划分血管瘤分期及监测治疗效果提供客观的依据。

Objective To investigate the urine concentration of bFGF in order to distinguish hemangioma from vascular malformation and mark off different phases of hemangioma.Methods ELISA (enzyme linked immunosorbent assay) was used to determine urine bFGF concentration of 29 patients with proliferative hemangioma,24 with involuting hemangioma,12 with vascular malformation and 10 infants of the control group.Results The urine bFGF concentrations of 29 proliferative hemangioma patients were significantly higher than those of involuting hemangioma patients,vascular malformation patients and control group infants,and the difference of urine bFGF concentration between involuting hemangioma,vascular malformation and the control group both had statistical significance.Conclusion ELISA could easily and accurately determine the urine bFGF concentration, and it could provide a project index to not only distinguish hemangioma from vascular malformation but also mark off different phases of hemangioma and evaluate the curative effect as well.