早期隐性梅毒患者细胞免疫变化

Changes of Cellular Immunity in Patients with Primary Latent Syphilis

目的研究早期隐性梅毒患者细胞免疫变化。方法采用流式细胞仪分别检测12例早期隐性梅毒患者(A组)、12例二期梅毒患者(B组)外周血T淋巴细胞亚群,ELISA法分别检测两组血清白细胞介素12(IL12)水平。结果两组外周血CD4+T细胞数、CD4/CD8比值均低于正常对照组(P均<0.01),两组血清IL12水平均高于正常对照组(P均<0.01)。A组外周血CD4+T细胞数、CD4/CD8比值、血清IL12水平均低于B组(P均<0.01)。A组外周血CD8+T细胞数高于B组(P<0.01)。结论早期隐性梅毒患者存在较二期梅毒患者更显著细胞免疫低下现象。

Objective To study the changes of cellular immunity in patients with primary latent syphilis.Methods Peripheral blood T lymphocyte subgroups were assessed with flow cytometry(FCM) and serum interleukin 12(IL 12) level was determined by ELISA in 12 primary latent syphilis patients and 12 secondary syphilis patients respectively.Results The number of CD4 +T cells and the ratio of CD4/CD8 in patients with latent syphilis (A group) or secondary syphilis (B group) were lower than that in control group( P <0.01). The level of serum IL 12 increased significantly in A or B group as compare to that of control group( P <0.01). The number of CD4 +T cells, the ratio of CD4/CD8 and the level of serum IL 12 in A group were lower than those in B group ( P <0.01).Conclusion There is a more prominent suppression of the function of cellular immunity in patients with primary latent syphilis than that in the patients with secondary syphilis.