山莨菪碱对脂肪栓塞综合征的防治作用

The effect of anisodamine on fat embolism syndrome

目的 探讨山莨菪碱对脂肪栓塞综合征 (FES)的防治作用及其机制。方法 实验动物随机分成对照组和用药组 ,两组采用油酸静脉注射诱发FES ,用药组接受山莨菪碱治疗。观察其丙二醛、血浆纤维连接蛋白、动脉血氧分压及病理改变。结果 栓塞后对照组的丙二醛明显升高 ,血浆纤维连接蛋白和动脉血氧分压显著下降 ;用药组的丙二醛无明显升高 ,血浆纤维连接蛋白在 2 4、 4 8h ,PaO2 在 12、 2 4、 4 8h的时候显著高于对照组 ,病理改变也明显减轻。结论 氧自由基损伤和血浆纤维连接蛋白持续减少与FES的发生有关 ,山莨菪碱对FES有一定的防治作用 。

Objective To investigate the preventive and therapeutic effects of anisodamine on fat embolism syndrome(FES)and its mechanism.Methods The experimental rabbits were randomly divided into control group and treatment group.FES was induced by intravenous infusion of oleic acid in the both groups,and the treatment group received anisodamine therapy.Malondial dehyde(MDA),plasma fibronectin(Fn),partial pressure of arterial oxygen(PaO 2)and pathological changes in the lung,heart,and kidney were observed.Results MDA increased,and Fn and PaO 2 decreased in the control group after FES.In the treatment group,there was no obvious increase in MDA after FES,a slower decrease of Fn at 24,48 h after FES,and a slower decrease in PaO 2 at 12,24,48 h.The pathological changes in the treatment animal demonstrated much less injury.Conclusion The continuous increase of oxygen free radicals and decrease in the plasma fibronectin is related to occurrence of the fat embolism syndrome.Anisodamine is effective on FES,and the mechanism may be its effect on MDA and Fn.