克山病患者肝炎及柯萨奇病毒感染的观察

Studies on hepatitis and Coxsackie virus antibodies in Keshan disease patients

目的通过测定慢型、潜在型克山病患者血清中肝炎及柯萨奇病毒抗体的水平,探讨克山病病毒感染学说。方法选择黑龙江省富裕县克山病病区慢型、潜在型克山病患者34例,健康人32例。病毒抗体的测定采用ELISA方法,统计学使用病例对照研究的方法。结果C型肝炎抗体(HCV鄄IgM)阳性的OR是9.54(95%信赖区间1.07∽∞),有统计学意义。结论从C型肝炎病毒抗体(HCV鄄IgM)的阳性率在克山病患者中明显增高的这一结果推测,C型肝炎病毒的感染可能在克山病的发生、发展中起一定的作用。

To investigate the effects of viral infections on Keshan disease(KSD) by detecting hepatitis B surface antibody(HBsAg)?hepatitis C(HCV-IgM) and the specific antibodies against Coxsackie virus(CVB-IgG, CVB-IGM) in the serums of patients with chronic and potential KSD. Methods 34 patients with KSD and 32 healthy controls were selected from the epidemic area of keshan disease. ELISA method was used to detect the virus antibo dies. Statistical comparisons were made using chi-spuare test. Results The odds ratios of the positive antibodies against hepatitis virus C was 9.54 (95% confidence intervals1.07∽∞), It was statistic significance. Conclusions It is supposed that infection of hepatitis C may play a role in KSD's mechanisms as the positive rate of HCV-IgM antibody is significantly increased in the KSD patients.