子宫内膜异位症患者宫内膜异位内膜组织中CD44、TGF-β_1的表达

Expressions of CD44 and transforming growth factor-β_1 in endometrium and ectopic endometrial tissues in endometriosis patients

目的 探讨CD44和转化生长因子 β1 (TGF β1 )与子宫内膜异位症 (endometriosis ,EM)的关系。方法 采用免疫组化技术对EM在位子宫内膜和卵巢异位子宫内膜各 17例、对照组子宫内膜 2 0例分别进行组织病理学观察和CD44、TGF β1表达的检测。结果 EM的在位子宫内膜CD44和TGF β1 的表达和对照组相比无显著差异 ;卵巢异位子宫内膜上皮细胞CD44和TGF β1 的表达显著高于对照组。结论 提示EM异位内膜CD44和TGF β1 的异常表达可能与EM的发生、发展有关。

Objective To explore relationship of CD44 and transforming growth factor-β 1 (TGF-β 1) in endometriosis (EM) patients. Methods The histopathological changes and the expressions of CD44 and TGF-β 1 were observed and determined by immunohistochemistry in 17 cases of ectopic endometrium of EM patients and 17 cases of ovarian ectopic endometrium of EM patients. The other 20 cases of non-endometriosis and non-tumorous endometrial tissues were used as the control group. Results No difference in the expressions of CD44 and TGF-β 1 was found in the ectopic endometrium of EM patients and the control group, but the expressions in the ovarian ectopic endometrium of EM patients were significantly higher than those in the control group. Conclusion The abnormal expressions of CD44 and TGF-β 1 in ectopic endometrium of EM patients may be associated with the genesis and progression of EM.