妊娠期肝内胆汁淤积症患者CG值、S/D值及NST检测与新生儿预后的关系

Relationship of cholyglycine, blood flow of fetal umbilical artery, and non-stress test in patients with intrahepatic cholestasis of pregnancy

目的 探讨妊娠期肝内胆汁淤积症患者血清甘胆酸、胎儿脐动脉血流测定及产前胎心监护对新生儿预后的预测价值。方法 应用放免法测定血清甘胆酸 (cholyglycine ,CG)、超声多普勒测定胎儿脐动脉血流速度比值 (non stresstest ,S D)及胎心监护仪监测胎心率 (NST) ,记录分娩方式、新生儿出生Apgar评分等。结果 随着CG值的升高 ,异常S D值和NST结果的发生率显著增高 (P <0 0 5 ) ;当伴有异常CG值、S D值或NST结果时 ,新生儿窒息发生率和因胎儿宫内窘迫而施剖宫产率明显增加。结论 CG、S D值及NST结果与围产儿缺氧密切相关 ,是判断新生儿预后的可靠和重要的指标。

Objective To explore the predicting value of serum cholyglycine (CG), determination of the blood flow of fetal umbilical artery (S/D), non-stress test (NST) results in the prognosis of the newborns. Methods Serum CG, S/D, NST results in 110 cases of intrahepatic cholestasis of pregnancy were determined by radioimmunoassay, color Doppler ultrasonic instrument, and fetal electronic wardship instrument, respectively. The delivery modes and postnatal Apgar scores were recorded. Results CG levels increased the incidence of abnormal S/D and NST in a dose-dependent manner (P<0.05); The occurrence rate of apnea in the newborn and cesarean section rate due to fetal distress were significantly in creased in the groups of abnormal CG or S/D or NST. Conclusion CG, S/D, and NST, closely associated with apnea in the newborn, may be the reliable and important prognostic factors for predicting the prognosis of the newborns of women with intrahepatic cholestasis of pregnancy.