粘膜相关淋巴组织淋巴瘤临床病理研究

Study on the Clinical and Pathological Features of the Mucosa-associated Lymphoid Tissue(MALT) Lymphomas

目的 :探讨粘膜相关淋巴组织 (MALT)淋巴瘤临床病理特征。方法 :对我院确诊和会诊的粘膜相关淋巴瘤 18例 ,进行临床病理分析。按原发部位分为胃肠 (GI)和非胃肠 (NON -GI)两组 ,男性 11例 ,女性 7例 ,男女之比为 1 6∶1,平均年龄 5 2岁 (31岁～ 6 3岁 )。结果 :GI组 9例 ,临床表现无特异性 ,以腹部疼痛最常见 ,占本组78% (7/9) ,其次是腹部包块 ,占 33% (3/9) ,内镜下表现多样 ;NON -GI组 9例 ,以局部无痛性包块为主。手术后标本行免疫组化染色 ,结果均为B细胞恶性淋巴瘤。结论 :粘膜相关淋巴组织 (MALT)淋巴瘤是非霍奇金淋巴瘤的一种亚型 ,具有起病隐匿 ,病程长 ,进展慢及患病率低 ,好发于中老年男性 ,治疗和预后良好等特征。

Objective:?To explore the clinical and pathological features of MALT lymphoma.Methods:?18 cases of MALT lymphoma were analyzed for clinical and pathological features. The patients were divided into the gastro-intestinal (GI) and non-GI groups according to the origin of primary tumor. Among them, 11 were male and 7 were female with a ratio of 1.6∶1; the mean age was 52 years (31～63 years).Results:?For the 9 cases of the GI group, the symtoms and signs were non-specific, with abdominal pain as the most common (78%,7/9) and abdominal mass as the second (33%,3/9); the endoscopic fearures were varied. For 9 cases of the non-GI group, the majar symptom and sign was painless abdominal mass. The postoperative immunohistochemical study of the samples demonstrated that all were malignant B cell lymphoma.Conclusion:?MALT lymphoma is a subtype of non-Hodgkin's lymphoma which is featured by latent onset, long disease course, slow progression and low incidence, often attacking mid-and old age males, and having good prognosis.