胃腹气痛胶囊对胃运动功能的影响及其抗溃疡作用

An Experimental Study of the Weifuqitong Capsule with Res pect to Its Effect on the Gastric Motor Function and Its Ulcer-proventive Action

目的 :研究胃腹气痛胶囊对胃运动功能的影响及其抗溃疡作用 ,为其临床应用提供实验依据。方法 :通过小鼠胃排空实验和豚鼠体内胃运动实验研究胃腹气痛胶囊对胃运动功能的影响 ,通过水浸应激诱导大鼠胃溃疡模型研究胃腹气痛胶囊的抗溃疡形成作用。结果 :胃腹气痛胶囊水溶性成分皮下注射可显著抑制小鼠胃排空 (P <0 .0 1) ;胃腹气痛胶囊低剂量和中剂量灌胃给药可显著增强豚鼠胃蠕动 ,而高剂量则明显减弱胃蠕动 (P <0 .0 5 ) ;胃腹气痛胶囊也可呈剂量依赖性抑制大鼠应激性胃溃疡形成 (P <0 .0 1)。结论 :胃腹气痛胶囊对胃运动功能表现为低剂量兴奋、高剂量抑制的双向调节作用 ,可显著拮抗应激性溃疡形成 ,可能是治疗胃脘疼痛的有效药物。

Objective:To study the effect of the weifuqi tong capsule on the gastric motor function as well as its ulcer-proventing ac tion in laboratory animals so as to provide experimental basis for its clinical application. Methods:The effect of the weifuqitong capsule on the gastric motor function was examined with a gastric emptying test in the mouse a nd an in vivo gastric motor function test in the guinea pig.A rat model of stres s ulcer of stomach was set up by immerging the animals into water to the level o f the xiphoid process for 24 hours and this model was used to study the ulcer-p reventing action of the drug. Results:Hypodermic injection of the water-soluble compo nents of the weifuqitong capsule was shown to strikingly inhibit the gastric emptying in the mouse(P<0.01). When administered by gastrogavage, weifuq itong capsules in low and medium doses notably enhanced gastric peristalsis in the guinea pig, while high dose of the drug had the opposite effect(P<0.05 ). The weifuqitong capsule was also shown to decrease the rate of stress ulc er formation in the rat in a dose-dependent manner(P<0.01). Conclusion:A bidirectional regulatory effect of the we ifuqitong capsule on the gastric motor function was manifested by that low dos e of the drug excited while high dose inhibited the function in the animals. The drug was also shown to notably inhibit gastric stress ulcer formation in the r ats. It may thus be an effective remedy for the treatment of epigastralgia.