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治疗注意缺陷障碍的新药——托莫西汀 被引量：10

Atomoxetine:a new medicine for the treatment of attention deficit hyperactivity disorder
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摘要 盐酸托莫西汀(简称托莫西汀)是获美国食品药品管理局批准不久的新药,用于治疗儿童、青少年和成人注意缺陷障碍(ADHD)。其可能的作用机制是阻断突触前膜去甲肾上腺素转运体。迄今为止,托莫西汀已经在2 500多名ADHD儿童和青少年以及350多名ADHD成人患者中进行了安慰剂对照研究和开放性研究,其在缓解ADHD症状方面均明显优于安慰剂,并且有很好的安全性和耐受性。
作者 魏宏伟
机构地区 第二军医大学附属长征医院儿科
出处 《国外医学（儿科学分册）》 2004年第6期329-332,共4页 Foreign Medical Sciences（Section of Pediatrics)
关键词 注意力缺陷障碍伴多动 中枢神经系统药物
分类号 R971 [医药卫生—药品]
  • 相关文献

参考文献14

  • 1Kratochvil CJ, Heligenstein JH, Dittmann R, et al. Atomoxetion and methylphenidate treatment in children with ADHD: a prospective,randomized, open-label trial [J]. J Am Child Adolesc Psychiatry, 2002, 41(7) :776-784.
  • 2Schachter HM, Pham B, King J, et al. How efficacious and safe is shortacting methylphenidate for the treatment of attention-deficit disorder inchildren and adolescents? A meta-analysis[J]. CMAJ, 2001, 165(11):1475-1488.
  • 3Bymaster FP, Katner JS, Nelson DL, et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention-deficit/hyperactivity disorder [J].Heuropsychopharmacology, 20
  • 4Michelson D, Faries D, Wernicke J, et al. Atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, dose-response study [J]. Pediatrics, 2001,108(5): E83-86.
  • 5Simpson D, Perry CI.Atomoxetion[J] .Paediatr Drugs,2003,5(6):407-417.
  • 6Wender PH, Wolf LE, Wasserstein J,et al. Adults with ADHD. An overview [J] .Ann N Y Acad Sci,2001,931(4): 1-16.
  • 7Wernicke JF,Kratochvil CJ.Safety profile of atomoxetine in the treatment of children and adolescents with ADHD[J]. J Clin Psychiatry, 2002,63 (Suppl 12) :50-55.
  • 8Wernicke J,Faries D,Girod D,et al. Cardiovascular effects of atomoxetine in children, adolescents, and adults[J]. Drug Saf, 2003,26(10): 729-740.
  • 9Barr GL, Kroft J, Feng Y, et al. The norepinephrine transporter gene and attention-deficit hyperactivity disorder[J]. Am J Med Genet,2002,114(3):255-259.
  • 10Guengerich FP. Cytochrome P450 proteins and potential utilization in biodegradation[J].Environ Health Perspect, 1995,103(Suppl 5):25-28.

同被引文献33

  • 1杜亚松.注意缺陷多动障碍的临床特征及其诊断[J].中国实用儿科杂志,2005,20(9):515-518. 被引量：8
  • 2伍季,王华栋,刘红伟,屈凌波.紫外分光光度法测定盐酸托莫西汀胶囊的含量[J].河南科学,2006,24(3):356-357. 被引量：5
  • 3朱俊娟,陆峥.托莫西汀治疗成人注意缺陷多动障碍的效果[J].上海精神医学,2006,18(2):114-116. 被引量：1
  • 4王华栋,吕和平,吴拥军,屈凌波.化学发光法快速测定盐酸托莫西汀的含量[J].药物分析杂志,2007,27(3):348-350. 被引量：6
  • 5Jasiinski D R, Faries D E, Moore R J, et al. Abuse liability assessment of atomoxetine in a drug-abusing population [J]. Drug and Alcohol Dependence,2008, (95) : 140 - 146.
  • 6Patel C, Patel M, Rani S, et al. A new high performance liquid chromatographic method for quantification of atomoxetine in human plasma and its application for phannacokinetic study[ J]. J Chromatog B,2007,850( 1 - 2) :356.
  • 7Guo W,Li WB, Guo GX, et al. Determination of atomoxetine in human plasma by a high performance liquid chromatographic method with ultraviolet detection using liquid-liquid extraction[ J]. J Chromatog B, 2007, 854( 1 - 2) : 128.
  • 8Mullan JH, Shugert RL, Ponsler GD, et al. Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metaborites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS)[J] .J Pharm and Biomed Anal,2005, 38(4) :720.
  • 9Zhu HI, Wang JS, Donovan JL, et al. Sensitive quantification of atomoxetine in button plasma by HPLC with fluorescence detection using 4-(4,5-diphenyl-1H-imidazole-2-yl) benzoyl chloride derivafization[J]. J Chromatogr B,2007,846( 1 - 2) :351.
  • 10Patel C,Patel M,Rani S,et al. A new high performance liquid chromatographic method for quantification of atomoxetine in human plasma and its application for pharmacokinetic study [J]. Journal of Chromatography B, 2007,850(1-2) : 356.

引证文献10

二级引证文献16

国外医学（儿科学分册）
2004年 第6期

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