逐瘀通腑灌肠液对脑损伤脑脊液神经递质影响的临床研究

A Clinical Study of the Influence of Zhuyu Tongfu Enema on Nervous Transmitter of Cerebrospinal Fluid in Brain Injury

目的:观察逐瘀通腑灌肠液治疗颅脑损伤对脑损伤脑脊液神经递质的影响。方法:将90例颅脑损伤患者随机分为2组,基础治疗均采用西医常规疗法。治疗组60例加用逐瘀通腑灌肠液保留灌肠,对照组30例加用生理盐水保留灌肠。主要观察对5-羟色胺(5-HT)、去甲肾上腺素(NE)、肾上腺素(E)等脑脊液神经递质及颅内压、格拉斯哥(GCS)评分的影响。结果:治疗组治愈率、总有效率均高于对照组,2组比较,差异均有显著性意义(P<0.05)。治疗组治疗后脑脊液神经递质各项指标及颅内压均显著降低,并能提高GCS评分。结论:逐瘀通腑灌肠液治疗颅脑损伤早期患者,能够显著降低脑脊液神经递质各项指标及颅内压,提高GCS评分,改善临床症状,减少并发症,提高临床治愈率。

Objective: To observe the influence of Zhuyu Tongfu enema (ZTE) on nervous transmitter of cerebrospinal fluid in brain injury. Methods: 90 cases of craniocerebral injury (CI) were allocated to 2 groups randomly, the routine western medicine (WM) was applied as basic treatment. The treatment group (60 cases) was treated by ZTE for retention-enema (RE), and control group (30 cases) by adding normal saline for RE. The nervous transmitters of cerebrospinal fluid including 5-hydroxytryptamine (5-HT), nore pinephrine (NE) and epinephrine (E) , and the intracranial pressure (IP) were observed and Glasgow scoring (GCS) were evaluated. Results: The cured rate and total effective rate of treatment group was higher than that of control group ( P< . 05) . After treatment, various parameters of nervous transmitters of cerebrospinal fluid and IP were markedly decreased and the GCS was increased in treatment group . Conclusion: The ZTE for early stage of CI can markedly decrease various parameters of nervous transmitters of cerebrospinal fluid and IP, and increase GCS, improve clinical symptoms, decrease complications and increase the cured rate.