芪决六君子汤配合芬太尼透皮贴剂治疗晚期癌痛37例疗效观察

Treatment of Late-Stage Cancerous Pain By Qijue Liujunzi Tang Associated with Fentany Percutaneous Plaster: A Clinical Observation of 37 Cases

目的:观察芪决六君子汤配合芬太尼透皮贴剂治疗晚期癌痛的止痛效果及降低不良反应发生的作用。方法:将78例晚期癌症伴中重度疼痛患者随机分为2组。对照组40例,用芬太尼透皮贴剂治疗;治疗组38例,在对照组治疗基础上加服芪决六君子汤(药用黄芪、决明子、党参、白术、茯芩、陈皮、姜半夏、甘草等)治疗。2组均以15天为1疗程。结果:镇痛效果总有效率治疗组为92.1％,对照组为75.0％,2组比较,差异有显著性意义(P<0.05);而且治疗组能有效降低不良反应发生率。结论:芪决六君子汤配合芬太尼透皮贴剂治疗晚期癌痛能有效降低不良反应发生率,还可明显增强镇痛效果。

Objective: To observe the analgesic effect of Qijue Liujunzi Tang (QLT) associated with fentany percutaneous plaster for late-stage of cancerous pain and its action for reducing adverse reaction. Methods: 78 cases of late-stage cancer with intermediate-degree or severe pain were allocated to 2 groups randomly. The control group (40 cases) was treated by fentany percutaneous plaster; the treatment group (38 cases) by QLT (composed of Radix Astragali, Semen Cassiae, Rddix Codonopsis, Rhizoma A tractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparata and Radix Glycyrrhizae) other them fentany plaster. 15 days constituted a course of treatment. Results: The total rate of analgesia was 92. 1% and 75.0% in treatment and control group respectively ( P < 0. 05), and the adverse reaction was also decreased in treatment group. Conclusion: QLT associated with fentany percutaneous plaster can markedly decrease the adverse reaction and enhance the analgesic effect.