六味地黄丸对早期糖尿病肾病尿微量白蛋白的影响

The Influence of Liuwei Dihuang Wan on Urinary Protein in Early Stage of Diabetic Nephropathy

目的:观察六味地黄丸治疗早期糖尿病肾病尿微量白蛋白的疗效。方法:选择符合2型糖尿病肾病病变早期患者68例,随机分为治疗组38例,对照组30例。2组均以糖尿病饮食、口服降糖药等基础治疗,对照组同时口服开博通,治疗组在对照组基础上口服六味地黄丸。2组均治疗3月后检测尿微量白蛋白,进行治疗前后对比观察。结果:治疗组显效18例,有效15例,无效5例,总有效率86.84％。对照组显效10例,有效13例,无效7例,总有效率76.67％。2组总有效率比较,差异有显著性意义(P<0.05);2组治疗后尿微量白蛋白均有下降,治疗组治疗前后比较,差异有非常显著性意义(P<0.01),与对照组比较,差异有显著性意义(P<0.05)。结论:六味地黄丸能有效地降低早期糖尿病肾病尿微量白蛋白,对控制糖尿病肾病进程具有治疗作用。

Objective: To observe the effect of Liuwei Dihuang Wan (LDW) on urinary protein in early stage of diabetic nephropa thy (DN). Methods: 68 cases of type II DN were allocated to treatment group (38 cases) and control group (30 cases) randomly. Diabetic diet and oral use of hypoglycemic agents served as the basic treatment in both groups. Captopril was given in the control group, and LDW was added in the treatment group. After treated for 3 months, the urinary protein was examined and compared with that before treatment. Results: In treatment group, 18 cases were markedly effective, 15 cases effective and 5 cases ineffective, the total effective rate being 86. 84% and in control group 10, 13, 7 and 76. 67% respectively ( P < 0. 05). After treatment, the urinary protein were decreased in both groups but that in treatment group before and after treatment was very significantly different (P < 0.01), and also significantly different as compared with control group ( P < 0. 05). Conclusion: LDW can decrease the urinary mi croalbumin in early stage of DN and can control grogress of DN.