AsAb和SPIM与不明原因原发性不孕的相关性研究

RELATIONSHIP BETWEEN ASAB,SPIM AND PRIMARY STERILITY FOR UNKNOWN REASON

应用ELISA 法测定了40对“不明原因”的原发性不孕夫妇血清,宫颈粘液,精浆中AsAb,用抗补体法对精浆中SPIM 含量进行了测定并与正常对照组对比,发现不孕组女性血清及宫颈粘液中AsAb阳性率分别为25.0%、40.0%,不孕组男性精浆中AsAb 阳性率为17.5%,均显著高于对照组,不孕组男性血清中AsAb 阴性率为10.0%与对照组相比无显著性差异。不孕组男性精浆中SPIM 含量显著低于对照组。认为;“不明原因”的原发性不孕夫妇的AsAb 阳性率较高,AsAb 主要分布于宫颈粘液和精浆中,且多发生于女性;高滴度的AsAb 和SPIM 含量减少是造成原发性不孕的重要原因。

Using the ELISA methoci,the AsAP in the serum mucus of utrusvertex and seminal fluid was determined to 40 couples with primary sterility for′′unknown reason′′.Using the anticomplementc method,the SPIM Content in theseminal fluid was measured and compared with the normal control group.It wasdiscovered that the positive rate of the sterilty group female serum and mucusof vertex was respectively 25.5% and 40.0%.The positive rate of A.sAb in malesemina fluid of sterilty group was 17.5%.All of the above were remarkablyhigher than those in the normal control group,The positive rate of AsAb inmale serum of sterility group was 10 0%,which was similar with that in thecontrol group.The content of SPIM in the male seminal fluid of sterility groupwas remarkably lower than that in the control group.It is suggested that theAsA.b positive rate for primary sterility for′′ unknown reason′′ couples is com-paratively higher.The AsA.b is easily found in the vertex of the uterus and theseminal fluid.The CaUSe of primary sterility is Clostly related wilh higher titrat-ion of AsAb and decreased content of SPIM