醋酸奥曲肽与奥曲肽治疗食管静脉曲张破裂出血的疗效比较

Therapeutic Effect of Octreotide Acetate vs Octreotide in Treatment of Patients with Esophageal Varices Accompanied with Upper Gastrointestinal Hemorrhage

目的 :观察醋酸奥曲肽治疗食管静脉曲张破裂出血的疗效。方法 :90例食管静脉曲张破裂出血患者分为两组 ,治疗组 6 0例用醋酸奥曲肽治疗 ,对照组 30例用奥曲肽治疗 ,观察并比较两组的疗效、止血时间、输血量。结果 :治疗组总有效率为 95 % ,对照组总有效率为 90 .0 %。两组间无统计学差异 (P >0 .0 5 )。两组止血成功患者在 2 4 ,4 8h的输血量分别为 :治疗组 (314 .3± 12 9.5 )ml,(44 5 .2± 312 .9)ml;对照组 (46 0 .0± 2 5 0 .3)ml,(6 6 1.5± 386 .3)ml,两组比较在统计学上有明显差异 (P<0 .0 5 )。结论 :醋酸奥曲肽的临床疗效优于奥曲肽 ,醋酸奥曲肽能有效、安全地治疗食管静脉曲张破裂出血。

Objective: To investigate the therapeutic effect of octreotide acetate in treatment of patients with esophagealvarices accompanied with upper gastrointestinal hemorrhage(UGH).Method: 90 in patients with esophagealvarices accompanied with UGH were divided into two groups,60 cases were given octreotide acetate, 30 cases, as controlled group, were given octreotide. The therapeutic effect, hemostasis time and volume of blood transfusion were observed and compared in both groups.Result: The effective rate was 95% in therapeutic group, 90%in controlled group. There was no difference between two groups ( P > 0.05 ). The volumes of blood transfusion in successful hemostasis patients were ( 314.3 ± 129.5 )ml and ( 445.2 ± 312.9 )ml in therapeutic group after 24 hours and 48 hours; ( 460.0 ± 250.3 )ml and ( 661.5 ± 386.3 )ml in controlled group,respectively, there was statistics difference between two groups ( P <0.05 ).Conclusion: The rapeutic effect of octreotide acetate is better than octreotide, octreotide acetate could be used to treat esophageal varices accompanied UGH effectively and safely,and being superior to octreotide.