加替沙星治疗急性细菌性呼吸道和泌尿道感染

Acute Bacterial Respiratory and Urinary Tract Infection Treating by Gatifloxacin

目的 :评价国产加替沙星注射液治疗急性细菌性呼吸道和泌尿道感染的有效性与安全性。方法 :采用区组随机、平行对照、多中心研究设计 ,加替沙星注射液与左氧氟沙星注射液均为 2 0 0mg ,ivd ,q12h ,疗程 5～ 14d。 结果 :本项试验实际入组 4 9例 ,其中加替沙星组 2 7例 ,左氧氟沙星组 2 2例 ,治疗结果加替沙星与左氧氟沙星组临床有效率分别为 96 .30 %与95 .4 5 % ,细菌清除率分别为 95 .2 4 %与 10 0 % ,不良反应发生率分别为 7.4 1%与 4 .5 5 % ,上述结果均无统计学差异。结论 :加替沙星与左氧氟沙星在治疗临床常见的敏感细菌引起的呼吸道、泌尿道感染均是安全、有效的抗菌药物。

Objective: To evaluate the efficacy and safety of domestic gatifloxacin injection in the treatment of acute bacterial respiratory and urinary tract infection.Method: A multi center randomized controlled clinical trial was conducted to compare the gatifloxacin and levofloxacin in the treatment of acute bacterial respiratory and urinary tract infection. The doses of both agents were 200 mg q12h by intravenous infusion which sustained for 30 to 60 min. The duration of therapy was 5 to 14 days in both groups.Result: Forty nine patients, were enrolled in this study, were divided into gatifloxacin group ( n =27) or levofloxacin group ( n =22). The overall effective rates and bacterial clearance rates were 96.30% and 95.24% in gatifloxacin group, 95.45% and 100% in levofloxacin group, respectively, the frequency of adverse drug reactions in both groups were 7.41% and 4.55% , respectively. No statistical significances were found in above data.Conclusion: Gatifloxacin and levofloxacin were effective and safe in the treatment of acute bacterial respiratory and urinary tract infection.