2型糖尿病及合并大血管病变糖尿病患者C反应蛋白水平观察

C-reactive protein levels in type 2 diabetes and diabetes with macrovascular complications

目的 观察C反应蛋白 (CRP)在 2型糖尿病 (DM )及DM合并大血管病变时的浓度变化。方法 用ELISA方法测定血清CRP水平。在 2型DM患者 (伴或不伴大血管病变 )、无糖尿病的大血管病变患者、空腹血糖受损 (IFG)者、糖耐量低减 (IGT)者以及正常对照组测定血清CRP水平。结果 IGT者、2型DM以及无糖尿病的大血管病变患者血清CRP水平明显增高 (P <0 .0 5～ <0 .0 0 1) ;2型DM伴有或不伴有大血管病变患者以及无糖尿病的大血管病变患者间血清CRP水平差异无显著性 ;大血管病变患者血清CRP水平较非大血管病变者明显增高 (P <0 .0 5 )。结论 CRP在 2型DM和动脉粥样硬化的发生发展中均具有致病作用 ;就致动脉粥样硬化而言 ,CRP是普通人群 (包括 2型DM )的一般危险因子 ,并非 2型DM的特殊危险因子。

Objective To investigate the C-reactive protein (CRP) concentrations in the pathogenesis of type 2 diabetes mellitus (DM) and its macrovascular complications. Methods Serum CRP levels were assayed by ELISA, which were determined in type 2 DM patients with or without macrovascular complication (88 and 64 cases respectively), non-DM patients presenting with macrovascular disease (72 cases), as well as impaired fasting glucose (IFG) (62 cases) or impaired glucose tolerance (IGT) (70 cases) patients and normal controls (80 subjects). Results In general, CRP levels in IGT patients, type 2 DM patients and non-DM patients presenting with macrovascular disease were higher than those of normal controls (P<0.05～<0.001), but there was no significant difference among CRP levels in type 2 diabetics with or without macrovascular complication and non-DM patients presenting with macrovascular disease. Hence serum CRP levels in patients presenting with macrovascular disease were significantly higher thanthoseinpatientswithout macrovascular disease (P<0.05). Conclusion CRP plays a role in the initiation and progression of type 2 DM and atherosclerosis. As for atherosclerosis, CRP is a common risk factor of general population (including type 2 DM), although CRP is not a special risk factor of type 2 DM.