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脑缺血预处理及其耐受机制的研究进展 被引量：1

The research progression in cerebral ischemia preconditioning and its tolerance mechanism
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摘要 :脑缺血预处理(brainischemicpreconditioning,BIP)及其耐受机制是近几年来神经科专家研究的热门课题。短暂局灶缺血诱导产生的局灶缺血耐受和患者经历多次短暂性脑缺血发作(transientischemicattack,TIA)的情况最相似。国内外学者运用多种脑缺血预处理模型对脑缺血耐受机制进行研究,多数人认为BIP一般机制为缺血预处理可引起组织释放以腺苷为主的内源性递质与相应的受体结合,通过激活信号传导通路启动特定的基因表达出具有保护作用的效应物。BIP产生的耐受是对缺血损伤产生的一种明显迟发并持续性的神经保护作用,今后可进一步研究将BIP现象用于脑退化性病变、创伤和放射性损伤的治疗。
作者 王金春 卢振春 孙锋 宋利春
机构地区 沈阳市第五人民医院神经内科 中国医科大学第二临床学院神经内科
出处 《中国临床康复》 CSCD 2004年第16期3099-3101,共3页 Chinese Journal of Clinical Rehabilitation
关键词 脑缺血 缺血预处理 综述文献
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献23

  • 1Ishida T, Yarimizu K, Gute DC, et al. Mechanism of ischemic preconditioning.Shock 1997; 8(2): 86-94
  • 2Kirschenbaum B, Pulsinelli WA. Posthoc phosphorylation of proteins derived from ischemic rat hippocampus, striatum and neocortex. Brain Res 1990;511(1): 21-9
  • 3Tauskela JS, Chakravarthy BR, Murray CL, et al. Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart. Brain Res 1999; 827 ( 1 - 2): 143 - 5
  • 4Kato H, Liu Y, Araki T, et al. Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects. Brain Res 1991; 553 (2):238 - 4
  • 5Chen J, Graham SH, Zhu RL, et al. Bilateral ischemic tolerance of rat hippocampus induced by prior unilateral transient focal ischemia: relationship to c-fos mRNA expression. Neuroreport 1996; 8 ( 1 ): 55 - 9
  • 6Belayev 1, Ginsberg MD. Bilateral ischemic tolerance of not hippocampus induced by prior unilateral focal ischemia relationship to c-fos mRNA. Neuroreport 1996; 8(1):55-9
  • 7Simon RP, Niiro M, Gwinn R. Prior ischemic stress proteins against experimental stroke. Neurosci lett 1993; 163:135 -7
  • 8Prruer U, Weih MK, Isaen NK, et al. Induction of tolerance in rat cortical neurons: hypoxic preconditioning. FEBS Lett 1997; 414 (1): 117 - 27
  • 9Bhen J, Graham SH, Zhu RL, et al. Stress proteins and tolerance to focal cerebral ischemia. J Cereb Flow Metab 1996; 16:566 -77
  • 10Matsushima K, Hakim AM. Transient forebrain lschemia protects against subsequent focal cerebral ischemia without changing cerebral perfusion. Stroke 1995;26:1047 -52

二级参考文献17

  • 1Ebadi M,Bashir RM, Heidrick ML. Neumtrophines and their receptors in nerve injury and repair. Neurochem Int, 1997,30:347 - 374.
  • 2Lindvall O, kduda Z, Bengzon J, et al. Nurotrophins and brain insults.TINS, 1994,17(11 ) :490 - 496.
  • 3Kokaia Z,Zhao Q,Kokaia M,et al.Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage.Exp Neurol,1995,136(1):73-88.
  • 4Lindvall Z,Emfors P, Bengzon J et al.Differential regulation of mRNA for nerve growth factor, brain- derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypogylycemie coma.Pine Natl Acad Scid USA, 1992,89(2) :648- 652.
  • 5Takemoto O,Tomimoto H,Yanagihara T.Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils.Stroke,1995,26:1639-1648.
  • 6Wang X,Li X,Currie RW,et al.Application of real-time polymerase chain reaction to quantities induced expression of interleukin-1 beta mRNA in ischemic brain bolerance.J Neurosci Res,2000,59(2):238-246.
  • 7Dekosky ST,Styren SD,O'Malley ME,et al.Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain,Ann Neurol,1996,39(1):123-127.
  • 8Nawashiro H,Tasaki K,Ruetzler CA,el al.TNF-alpha protreatment induces protective effects against focal cercbral ischemia in mice.J Cereb Blood Flow Metab,1997,17(5):483-490.
  • 9Hattori A,Tanaka E,Murase K,et al.Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.J Biol chem,1993,268(4):2577-2582.
  • 10Lascola C, Kraig RP. A stroglial acid - base dynamics in hyperglycemic and normoglycemic global ischemia. Neurosci Biobehav Rev, 1997,21 :143- 150.

共引文献39

同被引文献5

  • 1Weih M, Prass K, Ruscher K, et al. Ischemia tolerance; model for research,hope for clinical practice? Nervenarzt 2001:72(4):255-60
  • 2Barker PM, Nguyen MS, Gatzy JT, et al. Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.J Clin Invest 1998;102 (8):1634-40
  • 3Neubauer JA.Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol 2001:90(4):1593-9
  • 4高晓群,朱红灿,茹立强,殷光甫.缺血缺氧预适应的脑保护机制[J].中华老年心脑血管病杂志,2003,5(5):356-358. 被引量：1
  • 5吕国蔚,史美棠,李凌,安仰原.急性重复缺氧对小鼠缺氧耐受性的影响及其机制的初步探讨[J].中国病理生理杂志,1992,8(4):425-429. 被引量：95

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中国临床康复
2004年 第16期

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