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Sp1/Krüppel样转录因子家族研究进展 被引量：1

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摘要 Spl/Kruppel样转录因子(Spl-like and Kruppel-like tran- scription factors,Spl/KLFs)是参与真核细胞转录的高度相关锌指蛋白,以细胞和启动子特异性方式通过调控富含GC启动子的基因表达,参与调节细胞功能如细胞增生、凋亡、分化和肿瘤形成.
作者 张安平 张连阳
机构地区 中国人民解放军第三军医大学大坪医院野战外科研究所普通外科
出处 《世界华人消化杂志》 CAS 2004年第7期1641-1645,共5页 World Chinese Journal of Digestology
关键词 Sp1/Krüppel样转录因子 家族研究 细胞增生 细胞凋亡 肿瘤形成
分类号 R346 [医药卫生—基础医学]
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参考文献42

  • 1Turner J, Crossley M. Mammalian KriippeMike transcription factors: more than just a pretty finger. Trends Biochem Sci 1999;24:236-240.
  • 2Black AR, Black JD, Azizkhan-Clifford J. Spl and Kriippellike factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001;188:143-160.
  • 3Dang DT, Pevsner J, Yang VW. The biology of the mammalian KriippeMike family of transcription factors. Int J Biochem Cell Biol 2000;32:1103-1121.
  • 4Bieker JJ. Kriippel-like factors: three Fingers in many pies. J Biol Chem 2001;276:34355-34358.
  • 5rCook T, Gebelein B, Urrutia R. Spl and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. Ann NY Acad Sci 1999;880:94-102.
  • 6Philipsen S, Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 1999;27:2991-3000.
  • 7Suske G. The Sp-family of transcription factors. Gene 1999;238:291-300.
  • 8Ossipova O, Stick R, Pieler T. XSPR-1 and XSPR-2, novel Spl related zinc finger containing genes, are dynamically expressed during Xenopus embryogenesis. Mech Dev 2002;115:117-122.
  • 9Schock F, Purnell BAI V~immer EA, Jackle H. Common and diverged functions of the Drosophila gene pair D-Spl and buttonhead. Mech Dev 1999;89:125-132.
  • 10Oates AC, Pratt SJ, Vail B, Yan YL, Ho RK, Johnson SL,Postlethwait JH, Zon LI. The zebrafish klf gene family. Blood 2001;98:1792-1801.

同被引文献11

  • 1Bradford MM. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding[J]. Anal Biochem,1976,72(5):248-254
  • 2Artlett CM, Chen SJ, Varga J, et al. Modulation of basal expression of the human alpha 1 (Ⅰ) procollagen gene (COL1A1) by tandem NF-1/Sp1 promoter elements in normal human dermal fibroblasts[J]. Matrix Biol,1998,17(6):425-434
  • 3Nirodi CS, Devalaraja R, Nanney LB, et al. Chemokine and chemokine receptor expression in keloid and normal fibroblasts[J]. Wound Repair Regen,2000,8(5):371-382
  • 4Haase M,Geyer P, Appold S, et al. Down-regulation of SP1 DNA binding activity in the process of radiation-induced pulmonary fibrosis[J]. Int J Radiat Biol,2000,76(4):487-492
  • 5Buttner C, Skupin A, Rieber EP. Transcriptional activation of the type Ⅰ collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: analysis of the functional collagen promoter sequences[J]. J Cell Physiol,2004,198(2):248-258
  • 6Cicchillitti L, Jimenez SA, Sala A, et al. B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts[J]. Biochem J,2004,378(Pt 2):609-616
  • 7McKenna MJ, Nguyen-Huynh AT, Kristiansen AG. Association of otosclerosis with Sp1 binding site polymorphism in COL1A1 gene:evidence for a shared genetic etiology with osteoporosis[J]. Otol Neurotol,2004,25(4):447-450
  • 8Rippe RA, Almounajed G, Brenner DA. Sp1 binding activity increases in activated Ito cells[J]. Hepatology,1995,22(1):241-251
  • 9Leroy V, Monier F, Bottari S, et al. Circulating matrix metalloproteinases 1, 2, 9 and their inhibitors TIMP-1 and TIMP-2 as serum markers of liver fibrosis in patients with chronic hepatitis C: comparison with PIIINP and hyaluronic acid[J]. Am J Gastroenterol,2004,99(2):271-279
  • 10Lee M, Song SU, Ryu JK, et al. Sp1-dependent regulation of the tissue inhibitor of metalloproteinases-1 promoter[J]. J Cell Biochem,2004,91(6):1260-1268

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世界华人消化杂志
2004年 第7期

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