摘要
通过对多孔 HA/β- TCP生物陶瓷在炎性历程模拟体液 (Sim ulated body fluid,SBF)中动态浸泡 (即先在模拟炎性体液 p H6 .5的 SBF中动态浸泡 2 d,再在正常体液 p H7.4的 SBF中动态浸泡 12 d)的类骨磷灰石形成情况的研究后发现 ,模拟炎性历程的微酸性会溶解材料表面颗粒较细或曲率半径较小的部分 ,使材料表面变得光滑和溶解性能下降 ,在随后正常体液的 p H值下类骨磷灰石的形成量明显减少 ,这为理解钙磷生物陶瓷植入体内的诱导成骨机理和在体外筛选骨诱导性较好的钙磷材料提供了更可靠的方法。另外 ,实验结果还显示 ,用微波等离子体烧结的多孔 HA/β- TCP生物陶瓷 ,在正常 SBF和模拟了炎性历程的 SBF的动态实验中 ,其类骨磷灰石形成情况都好于用常规马弗炉烧结的样品 ,这预示用微波等离子体烧结的多孔 HA/β- TCP生物陶瓷可能具有更好的骨诱导活性。
The formation of bone-like apatite on porous HA/β-TCP bioceramics in dynamic simulated body fluid (SBF) undergoing a simulated inflammation procedure(pH=6.5) was investigated in order to study the mechanism of osteoinduction and build a new method to choose biomaterials with better bioactivity. The results showed that the surface of porous HA/β-TCP bioceramics which underwent a simulated inflammation procedure in dynamic SBF was more smooth. The light acidity in the simulated inflammation procedure would dissolve the fine grains and the parts possessing smaller curvature radius on the surface of porous HA/β-TCP bioceramics,which would reduce the bioceramics solubility. Followed in normal SBF(pH=7.4),the amount of bone-like apatite formed on the porous HA/β-TCP bioceramics was less than that of porous HA/β-TCP bioceramics incubation in normal SBF all along. The results also showed that the amount of bone-like apatite formed on the porous HA/β-TCP bioceramics sintered by a microwave plasma was more than that of porous HA/β-TCP bioceramics sintered by a conventional furnace.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2004年第4期531-535,共5页
Journal of Biomedical Engineering
基金
国家重大基础研究项目资助 ( 973 G19990 64 70 1)
