含氟聚醚聚氨酯与聚醚聚氨酯共混的表面结构及血液相容性的研究

Insight into Surface Structure and Hemocompatibility of Fluorinated Poly(ether urethane)s and Poly(ether urethane)s Blends

为了获得一种高氟聚氨酯表面 ,进一步改善聚醚聚氨酯的生物相容性和生物稳定性 ,将侧链含氟聚氨酯与聚醚聚氨酯共混而实现这一目的。通过 XPS、AFM、接触角和血小板黏附对含氟聚醚聚氨酯和聚醚聚氨酯共混物表面结构和血液相容性进行研究发现 ,在聚醚聚氨酯共混入极少量的氟 (0 .342 wt% )就能具有与含氟聚醚聚氨酯相同的表面结构和良好的血液相容性 ,而且共混物表面的强疏水性和对血小板的黏附与体系中混入的含氟聚醚聚氨酯的量无关 ,与表面

It has been well known that fluorinated polyurethanes exhibit unique low surface energy,biocompatibility,biostability and nonsticking behavior. Consequently,these polymers have attracted considerable interest. In this study,the effect of various concentrations of fluorinated polyurethanes in the polyurethanes on the surface structures of the blends and their hemocompatibility were investigated by XPS,AFM,contact angle and platelet adhesion. It was found that the high concentration fluorine on the outer surfaces of the blends obtained with the low concentration of fluorinated polyurethanes (F: 0.342 wt%) in the blends was the same as that of the fluorinated poly(ether urethane)s,and all of the blends and the fluorinated poly(ether urethane)s had good hemocompatibility,compared with poly(ether urethane)s. The polymer blends and fluorinated poly(ether urethane)s suppressed platelet adhesion due to their high hydrophobicity and low surface tension. The XPS,AMF and contact angle results indicated that the high hydrophobicity of outer surface of the polyurethane blends is independent of the fluorinated polyurethanes content in the polymer blends but related to the concentration of the CF 3 groups because the lower critical surface tensions and higher contact angle of many fluorinated surfaces reflect the concentration of CF 3 groups.