高强度聚焦超声在肿瘤治疗中的焦域模型

Necrosed Field Model of High Intensity Focused Ultrasound for Tumor Treatment

高强度聚焦超声 (High intensity focused ultrasound,HIFU)技术作为一种新兴的肿瘤微创外科治疗技术 ,正日益引起人们的高度重视。尤其是相对于某些浅表肿瘤 ,如乳腺癌 ,HIFU技术可以在保证治疗效果的同时 ,最大限度的减低治疗过程对患者的伤害。本文根据细胞热致死理论 ,利用 Ω值表达式法对 HIFU治疗过程中的焦域形成进行了仿真数学模型的建立 ,并通过非相干多元阵自聚焦系统建立实验模型进行试验 ,结果表明本文提出的焦域模型对实际加热过程的模拟是可靠的 。

High intensity focused ultrasound(HIFU) has become a new developed micro-invasive surgical treatment of tumor,which is a hot topic in basic and applied research field. HIFU has shown its unique advantages including micro-invasion and curative effect during the treatment of several kinds of superficial tumor, e.g. mammary cancer. Based on the cellular thermo-necrotic theory,the expression of Ω value was introduced to establish the mathematic model of the necrosed field formed in HIFU treatment progress. A non-interferential and self-focused system with multi-transducer was used to verify the theoretical model. Results of this study proved that the necrosed field mathematic model can simulate the actual heating progress. The model of this study may predict the practical value of the necrosed field as well as the time needed to take shape.