不同类型慢性HBV感染者外周血T细胞亚群的差异

Study of Different Subtype of T Cell among Various Types of Infected Person

目的 :比较HBV不同感染形式的患者外周血T细胞亚群的差异。方法 :采用流式细胞仪检测HBeAg阳性ALT异常者 40例 (A组 )、HBeAg阳性ALT持续正常者 2 0例 (B组 )、HBeAg及HBVDNA阴性ALT正常者 2 0例(C组 )、健康体检者 (各型肝炎病毒检测均为阴性 ) 15例 (正常对照组 )的外周血T细胞亚群。结果 :A、B组CD4+ T细胞数量较正常组及C组明显降低 ,CD8+ T细胞数量较正常组明显升高 ,CD4/CD8、CD8+ CD2 8+ 、CD2 8+ T细胞较正常组明显降低 ,而CD8+ CD2 8-T细胞则明显升高。结论 :HBeAg阳性ALT正常患者Ts细胞数量增多 ,TH细胞和CTL细胞受到抑制 ,乙肝病毒高度复制 ,与CD4+ T细胞及CTL数量低下 。

Objective:To research different immune status among various types of chronic HBV infectors, investigate correlation of hepatic function(serum ALT),HBV DNA,with subtype of T cells.Methods:80 patients of various types of chronic HBV infected person were observed,including 40 HBeAg positive with abnomal ALT,20 HBeAg positive with persistent nomal ALT,20 HBeAg and HBV DNA negative with persistent nomal ALT.Results:In HBeAg positive group, CD4^+ cells were little lower,and CD8^+ cells were little higher. To compare with HBV DNA≤10~3 Copies/ml group,CD4^+,CD8^+CD28^+ T cells were significantly lower, CD8^+ CD28^- T cells were significantly higher in HBV DNA 10~8 Copies/ml group(P<0.05,P<0.01). Concusions:There are differences in subtype of T cells among various types of chronic HBV infected Person.